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Effect of moderate dosage of chlorpropamide in pregnancy on fetal outcome

机译：怀孕期间适量氯丙酰胺对胎儿结局的影响

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The outcome of 19 pregnancies is reviewed in women receiving daily doses of at least 200 mg chlorpropamide for varying degrees of glucose intolerance. 4 required insulin in late pregnancy. In 13 mothers who had chlorpropamide during the first 13 weeks of pregnancy no fetal abnormality occurred. There were 2 intrauterine deaths, 1 neonatal death, 6 babies with birthweights greater than the 90th centile, and 2 with birthweights below the 10th centile. The total dosage taken during pregnancy varied from 5 to 105 g and the duration of administration varied from 3 to 39 weeks. Though the severity of diabetes loosely correlated with the daily chlorpropamide dosage, no constant relation existed between high daily dosage of chlorpropamide and obstetric or neonatal complications. It is concluded that it is more likely to be the poor control of the maternal diabetes in pregnancy than a pharmacological effect of the chlorpropamide on the fetal pancreas which is responsible for the poor results reported. 6 infants had intravenous glucose tolerance tests done within 3 hours of birth and the rate of glucose disposal and insulin response was found to be greater than in infants of untreated mothers with less severe diabetes.
机译：每天接受至少200 mg氯丙酰胺剂量的妇女因不同程度的葡萄糖耐量不佳而对19例妊娠的结果进行了回顾。妊娠晚期需要4种胰岛素。在怀孕的前13周内服用氯丙酰胺的13位母亲中，没有发生胎儿异常。有2例子宫内死亡，1例新生儿死亡，6例出生体重大于90％的婴儿，2例出生体重低于10％的婴儿。怀孕期间服用的总剂量为5至105克，给药时间为3至39周。尽管糖尿病的严重程度与每日服用氯丙酰胺的剂量松散相关，但每日服用高剂量的氯丙酰胺与产科或新生儿并发症之间并没有恒定的关系。结论是，与氯丙酰胺对胎儿胰腺的药理作用相比，怀孕期间对母体糖尿病的不良控制更有可能是造成不良结果的报道。 6例婴儿在出生后3个小时内进行了静脉葡萄糖耐量测试，发现葡萄糖治疗和胰岛素反应的发生率高于未接受治疗且糖尿病较轻的母亲。

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